Animal models are necessary for the stratification of products in development, through the evaluation of the immunogenicity, efficacy and safety of candidate drugs or vaccines.
We offer preclinical studies in the most common animal species, including:
- Non-human primates
Mice are widely used for the evaluation of vaccine immunogenicity. In addition to inbred (e.g., C57BL/6, BALB/C) and outbred (e.g., NIH swiss) mice, we use humanized mice to get better and more representative results regarding antibody responses to vaccination.
Ferrets are instrumental in understanding influenza virus pathogenicity and have served as pre-clinical models for the evaluation of vaccine candidates and new therapeutics. Although other small animal models have been used to study influenza, the ferret is the only animal model, which displays comparable clinical symptoms to that of humans upon influenza virus infection.
Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, and neurology, making them excellent experimental models for biomedical research. The value of NHPs as models for a variety of human infectious diseases is well documented. In some cases, they are the only non-human species susceptible to experimental infection with agents of human disease. Most importantly, NHPs typically provide the highest level of translational proof for immunogenicity, protective or therapeutic efficacy and safety.
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Cotton rats are increasingly used to study infectious diseases because of their unique susceptibility towards human pathogens. Mice and rats often are not or partially susceptible to human pathogens, and therefore rodent-adapted pathogen strains need to be produced and used. In contrast, the cotton rat has proven susceptible to a wide variety of human pathogens, including viruses.
Rabbits can be used as models for retroviruses, papilloma viruses, herpesviruses, and coronaviruses. In addition, rabbits are used for the production of polyclonal antibodies, which are important in the development of diagnostic assays.
Artemis Bio-support is a Contract Research Organization (CRO) specialized in the evaluation of viral vaccines and antiviral therapeutics.